Phosphodiesterase Inhibitors

Bioactive triterpenoids fromVochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4

Biological Sciences / Phytotherapy / Humans / Myrtaceae / CHEMICAL SCIENCES / Phosphodiesterase Inhibitors / Plant extracts / Isoenzymes / Cyclic nucleotides / Triterpenes / Phosphodiesterase Inhibitors / Plant extracts / Isoenzymes / Cyclic nucleotides / Triterpenes

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Tratamiento combinado de la hipertensión arterial pulmonar

Pulmonary Hypertension / Humans / Clinical Sciences / Phosphodiesterase Inhibitors / Combination drug therapy / Prostaglandins / Endothelins / Prostaglandins / Endothelins

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modelo de investigacion

Pulmonary Hypertension / Humans / Clinical Sciences / Phosphodiesterase Inhibitors / Combination drug therapy / Prostaglandins / Endothelins / Prostaglandins / Endothelins

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Hipertensión pulmonar tromboembólica crónica: tratamiento mediante tromboendarterectomía quirúrgica

Algorithms / Radiology / Praxis / Magnetic Resonance Imaging / Treatment Outcome / Pulmonary Hypertension / Prospective studies / Humans / Hemodynamics / Chronic Disease / Female / Pulmonary Embolism / Male / Follow-up studies / Differential Diagnosis / Radionuclide imaging / Incidence / Thromboembolism / Anticoagulants / Risk factors / Diagnostic Imaging / Recurrence / Clinical Sciences / Angiography / Phosphodiesterase Inhibitors / Aged / Prevalence / Cardiac Catheterization / Middle Aged / Image Enhancement / Adult / Respiratory / Carotid Endarterectomy / Prognosis / Risk Factors / Pyrazoles / Sensitivity and Specificity / X ray Computed Tomography / Medicina Clinica / Physical Exertion / Blood Flow Velocity / Mechanical Thrombectomy / Contrast Media / Magnetic resonance angiography / Pulmonary circulation / Pulmonary Artery / Postoperative Complications / Pulmonary Hypertension / Prospective studies / Humans / Hemodynamics / Chronic Disease / Female / Pulmonary Embolism / Male / Follow-up studies / Differential Diagnosis / Radionuclide imaging / Incidence / Thromboembolism / Anticoagulants / Risk factors / Diagnostic Imaging / Recurrence / Clinical Sciences / Angiography / Phosphodiesterase Inhibitors / Aged / Prevalence / Cardiac Catheterization / Middle Aged / Image Enhancement / Adult / Respiratory / Carotid Endarterectomy / Prognosis / Risk Factors / Pyrazoles / Sensitivity and Specificity / X ray Computed Tomography / Medicina Clinica / Physical Exertion / Blood Flow Velocity / Mechanical Thrombectomy / Contrast Media / Magnetic resonance angiography / Pulmonary circulation / Pulmonary Artery / Postoperative Complications

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Disfunción de la [Ca2+] diastólica en cardiomiocitos aislados de pacientes chagásicos

Calcium / Cell separation / Biopsy / Latin America / Humans / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium

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Disfunción de la [Ca 2+] diastólica en cardiomiocitos aislados de pacientes chagásicos

Calcium / Cell separation / Biopsy / Latin America / Humans / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium / Female / Male / Microelectrodes / Chagas disease / Phosphodiesterase Inhibitors / Middle Aged / Trypanosoma Cruzi / Adult / Chagas Cardiomyopathy / Phenylephrine / Boron Compounds / Intracellular Calcium

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Compartmentalized phosphodiesterase-2 activity blunts β-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

Calcium / Signal Transduction / Mice / cyclic AMP / Nitric oxide / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol / Animals / Feedback Control / Norepinephrine / Clinical Sciences / Phosphodiesterase Inhibitors / Rats / Cyclic nucleotides / Circulation / Adenine / cyclic GMP / Adenylyl Cyclase / Isoproterenol

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Soy polysaccharide as a novel superdisintegrant in sildenafil citrate sublingual tablets: preparation, characterization, and in vivo evaluation

Pharmaceutical Technology / Polysaccharides / Pharmaceutical Chemistry / Humans / Wettability / Male / Hardness / Solubility / Phosphodiesterase Inhibitors / Soybeans / Adult / Tablets / Excipients / Drug Stability / Biological Availability / Male / Hardness / Solubility / Phosphodiesterase Inhibitors / Soybeans / Adult / Tablets / Excipients / Drug Stability / Biological Availability

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Biophysical Characterization of Cyclic Nucleotide Phosphodiesterases

Protein Folding / Fluorescence / Arabidopsis thaliana / Saccharomyces cerevisiae / Circular Dichroism / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data / Escherichia coli / Urea / Biochemical / Arabidopsis / Phosphodiesterase Inhibitors / Cyclic nucleotides / Isothermal Titration Calorimetry / Calorimetry / Enzymatic Activity / X Ray Crystallography / Protein Denaturation / Biochemistry and cell biology / Molecular Sequence Data

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Compartmentalization of NO signaling cascade in skeletal muscles

Electron Microscopy / Skeletal muscle biology / Immunohistochemistry / Signal Transduction / Nitric oxide / Animals / Polymerase Chain Reaction / Biochemical / Enzyme / Phosphodiesterase Inhibitors / Skeletal Muscle / Rats / Nitric Oxide Synthase / Base Sequence / Biochemistry and cell biology / Sarcoplasmic reticulum / Animals / Polymerase Chain Reaction / Biochemical / Enzyme / Phosphodiesterase Inhibitors / Skeletal Muscle / Rats / Nitric Oxide Synthase / Base Sequence / Biochemistry and cell biology / Sarcoplasmic reticulum

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Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa

Endocrinology / Immunohistochemistry / Gene expression / Real-time RT-PCR / Western blotting / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Clinical Sciences / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP / Biological Sciences / Humans / Testosterone / Female / Animals / Male / Androgens / Prostate / Penis / tESTIS / Enzyme / Clinical Sciences / Phosphodiesterase Inhibitors / Late onset hypogonadism / Western blot / Protein Expression / Rabbits / Epididymis / Female To Male / Level / cyclic GMP

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Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity

Neuroscience / Psychology / Psychopharmacology / Animal Behavior / Schizophrenia / Memory / Startle Reflex / Prepulse Inhibition / Mice / ANOVA / Animals / Male / PPI / dopamine receptor D4 / Animal Model / Haloperidol / Phosphodiesterase Inhibitors / Pde / Side Effect / EPS / Second Messengers / Effective Dose / Neurosciences / Dextroamphetamine / Acoustic Stimulation / Memory / Startle Reflex / Prepulse Inhibition / Mice / ANOVA / Animals / Male / PPI / dopamine receptor D4 / Animal Model / Haloperidol / Phosphodiesterase Inhibitors / Pde / Side Effect / EPS / Second Messengers / Effective Dose / Neurosciences / Dextroamphetamine / Acoustic Stimulation

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Extracellular purines from cells of seminiferous tubules

Kinetics / Enzyme Inhibitors / Male Reproduction Health / Adenosine / Molecular and cellular biology / Germ Cells / Animals / Male / Sertoli cells / Phosphodiesterase Inhibitors / Rats / Wistar Rats / Sertoli Cell / Adenine / Extracellular Space / Germ Cell / Molecular and Cellular Biochemistry / Nucleotides / Biochemistry and cell biology / Adenosine Triphosphate / Adenosine Diphosphate / Seminiferous tubules / Germ Cells / Animals / Male / Sertoli cells / Phosphodiesterase Inhibitors / Rats / Wistar Rats / Sertoli Cell / Adenine / Extracellular Space / Germ Cell / Molecular and Cellular Biochemistry / Nucleotides / Biochemistry and cell biology / Adenosine Triphosphate / Adenosine Diphosphate / Seminiferous tubules

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Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade

Cystic Fibrosis / Signal Transduction / Humans / Nitric oxide / Pseudomonas aeruginosa / Phosphodiesterase Inhibitors / Sodium channel / Pseudomonas Aeruginosa / Hydrogen-Ion Concentration / Endosomes / Guanylate Cyclase / cyclic GMP / Biochemistry and cell biology / Phosphodiesterase Inhibitors / Sodium channel / Pseudomonas Aeruginosa / Hydrogen-Ion Concentration / Endosomes / Guanylate Cyclase / cyclic GMP / Biochemistry and cell biology

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Biochemical analysis of ecto-nucleotide pyrophosphatase phosphodiesterase activity in brain membranes indicates involvement of NPP1 isoenzyme in extracellular hydrolysis of diadenosine polyphosphates in central nervous system☆

Kinetics / Aging / Neurochemistry /  Enzymatic hydrolysis / Animals / Male / Frontal Cortex / Central Nervous System / Rat Brain / Neurons / Temporal Cortex / Enzyme / Phosphodiesterase Inhibitors / Rats / Age Factors / SYNAPTOSOMES / Wistar Rats / Hydrolysis / Neurosciences / Plasma Membrane / Nucleotides / Neuroprotective Agents / Male / Frontal Cortex / Central Nervous System / Rat Brain / Neurons / Temporal Cortex / Enzyme / Phosphodiesterase Inhibitors / Rats / Age Factors / SYNAPTOSOMES / Wistar Rats / Hydrolysis / Neurosciences / Plasma Membrane / Nucleotides / Neuroprotective Agents

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Tadalafil Relieves Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

Nephrology / Urology / Humans / QOL / Male / The / Clinical Sciences / Phosphodiesterase Inhibitors / Aged / Middle Aged / Urinary Tract / Benign Prostatic Hyperplasia / Adverse Event / Pde / Indexation / Flow Rate / Benign Prostate Hyperplasia / Lower Urinary Tract Symptoms / The / Clinical Sciences / Phosphodiesterase Inhibitors / Aged / Middle Aged / Urinary Tract / Benign Prostatic Hyperplasia / Adverse Event / Pde / Indexation / Flow Rate / Benign Prostate Hyperplasia / Lower Urinary Tract Symptoms

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